Dihydromyricetin (DHM), ACS – CAS 27200-12-0

Dihydromyricetin (DHM), also called ampelopsin, is the major flavonoid in Ampelopsis plants, primarily in the species grossedentata; it's also found in some other plant species, such as the Japanese raisin tree, Hovenia dulcis; these plants have been used as part of traditional Asian medicine, due to their reported anti-inflammatory, antioxidant, and anti-cancer properties, which have more recently been attributed to their high DHM content; DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties; in preclinical animal models, DHM shows a variety of beneficial anti-aging properties, by reducing inflammation, oxidative stress, lipidemia, as well as regulating energy metabolism and promoting autophagy; these effects are primarily derived from its ability to activate sirtuins. However, the magnitude of the benefits seen in preclinical studies has not yet translated to the effects seen in clinical trials, likely due to the poor stability and bioavailability of currently available DHM preparations