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Chloroquine diphosphate salt, ACS – CAS 50-63-5

Price f.o.b. for gr.100
€ 460.00

CAS Number: 50-63-5 Category:

Additional information

Weight 100 g
product name

Chloroquine diphosphate salt, ACS
synonyms

N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine diphosphate,
N4-(7-Chloro-4-quinolinyl)-N1,N1 dimethyl-1,4-pentanediamine diphosphate salt,
chloroquine,
bis(phosphoric acid)
product origin

100% made in European Union (according to USP, EUP, ECHA-REACH)
purity grade

>99.99% (raw virgin matter, ultra-pure, sterilized)
use

lab. / tech. / bio-research / compound
product code

EA0001
C.A.S. number

50-63-5
MDL

MFCD00069852
EINECS

200-055-2
ID PubChem substance

24278090
InChl key

QKICWELGRMTQCR-UHFFFAOYNA-N
SMILES

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
formula molecular

C18H32ClN3O8P2
empirical formula

C18H26ClN3·2H3PO4
formula weight

515.86
boiling point

947 °C
melting point

192 °C to 198 °C
density

1.239 g/cm3
flash point

526.6 °C
solubility

freely soluble in methanol and ethanol, suitable solubility in isopropanol, estimated solubility in water of 1.1X10-4 mg/L @ 25°C
stability

light sensitive
loss on drying

=<2 % (105°C, 16 h)
antibiotic activity spectrum

parasites
materials to avoid

strong oxidizing agents
mode of action

enzyme ; inhibits
infrared spectrum

conforms
refractive index

1.599
sensitivity & storage

ambient temperature
assay (HPLC)

>99.99%
appearance (color)

white to beige
form

powder
description

Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.
• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action.
• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens.
• This compound shows anti-malarial activity against Plasmodium falciparum, except against chloroquine-resistant strains; it has been used in in vitro antiplasmodial assays; in parasites the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.
• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM.
• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs
• Chloroquine diphosphate salt has been used in autophagy inhibition studies
note (1)

conditions to avoid :
incompatible products;
excess heat;
avoid dust formation;
exposure to light
note (2)

this product is for research use only, is not to be used for therapeutic ; not intended for animal or human or diagnostic or therapeutic use , and cannot be sold to patients.
note (3)

described price of the product is NOT NEGOTIABLE , already around 25% lower than the official price of the International Chemical Stock Exchange / ICIS .

* Possible additional discount for large quantity orders .
packaging / transport

special for chemical transport (according to IATA / ADR / ECHA-REACH rules / int.l laws) .
certifications

C.O.A., MSDS, GMP, API, USP, EUP, ECHA-REACH, ORIGIN, etc… (originals will be delivered with good , and copies after confirmed order)

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