Canrenone, ACS – CAS 976-71-6
Price f.o.b. for gr.1
€ 1,550.00
Additional information
| Weight | 1 g |
|---|---|
| product name | Canrenone, ACS |
| synonyms | (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713 |
| product origin | 100% made in European Union (according to USP, EUP, ECHA-REACH) |
| purity grade | >99.99% (raw virgin matter, ultra-pure, sterilized) |
| use | lab. / tech. / bio-research |
| product code | EA0238 |
| C.A.S. number | 976-71-6 |
| MDL | MFCD00071735 |
| EINECS | 213-554-5 |
| PubChem substance | 329825921 |
| formula molecular | C22H28O3 |
| formula weight | 340.46 |
| melting point | 149 °C to 151 °C |
| solubility | DMSO: 20 mg/mL, clear |
| optical activity | [α]/D +17 to +24°, c = 1 in chloroform-d |
| sensitivity & storage | ambient temperature, |
| assay (HPLC) | >99.99% |
| appearance (color) | white to beige |
| form | powder |
| applications | Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload. Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone. |
| note (1) | inhibits aldosterone biosynthesis and blocks ouabain effects |
| note (2) | this product is for research use only, is not to be used for therapeutic ; not intended for animal or human or diagnostic or therapeutic use , and cannot be sold to patients. |
| note (3) | described price of the product is NOT NEGOTIABLE , already around 25% lower than the official price of the International Chemical Stock Exchange / ICIS . * Possible additional discount for large quantity orders . |
| packaging / transport | special for chemical transport (according to IATA / ADR / ECHA-REACH rules / int.l laws) . |
| certifications | C.O.A., MSDS, GMP, API, USP, EUP, ECHA-REACH, ORIGIN, etc… (originals will be delivered with good , and copies after confirmed order) |
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