technical file | : | C.O.A. |
product name product origin purity grade use product code C.A.S. number MDL EINECS ID PubChem NACRES molecular formula lmolecular weight assay (HPLC) quality level storage & sensitivity solubility appearance (color) form description x x note (1) note (2) packaging/transport standardization | : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : | Suramin hexasodium salt, ACS - sterilized 100% made in European Union *(according to USP, EUP, Echa-Reach) >99.99% (raw matter, ultra-pure, selected) lab. / tech. / pharmaceutical / bio-research / dietary supplement EA61707129-46-4 MFCD00210217 204-949-3 24277738 NA.25 C51H34N6Na6O23S6 1429.16 >99.99% to <101.5% 200Store in cool place; keep container tightly closed in a dry and well-ventilated place (5 °C to 25 °C). Soluble in water and saline (turbidity) <15% (H2O >10 mg/mL); sparingly soluble in 95% bethanol . white to pale cream powder Suramin is an antiparasitic drug , which blocks endothelial cell proliferation and increases tyrosine phosphorylation of many signalling proteins; associated with urticaria, paresthesias, vomitino and neurologic toxicity; Suramin is used to treat trypanosomiasis and onchocerciasis; it functions as an heparanase inhibitor and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property. Suramin sodium salt has been used: - as a potent blocker of rat P2Y2 purinergic receptor - to study its effects on short circuit current (Isc) across strial marginal cells - to show its effects on initial burst of glial activity - to assess its neuroprotective potential in rats - as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP) . Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M along with SIRT5 has also been observed ; Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase , FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF ; it is used as a G protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5 ; it also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors; increases open probability of ryanodine receptor (RyR) channels ; anticancer and antiviral agent . Store in cool place ; keep container tightly closed in a dry and well-ventilated place *(1) ; keep away from strong oxidizing agents *(1) . 2 (two) years from production date (sealed package) , * shipped in ambient (1) . This product is for research use only, is not to be used for therapeutic; not intended for animal or human or diagnostic or therapeutic use , and cannot be sold to patients. Special for chemical transport (according to IATA / ADR / ECHA-REACH rules / int.l laws) According to U.S. / E.U. Pharmacopoeia, Echa-Reach, UNI EN ISO 14001, G.M.P., M.S.D.S., etc... |
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