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Suramin Hexasodium Salt , ACS - sterilized
100% made in European Union (according to USP, EUP, ECHA-REACH)
>99.99+% min. (raw virgin matter, ultra-pure)
lab. / tech / pharma / bio-research
EA61707
129-46-4
MFCD00210217
204-949-3
24277738
NA.25
C51H34N6Na6O23S6
1429.16
>99.99% to <101.5%
200
store in cool place; keep container tightly closed in a dry and well-ventilated place *5 °C/25 °C
in water and saline (turbidity) <15% (H2O >10 mg/ml); sparingly soluble in 95% bethanol
white to pale cream
powder
Suramin is a antiparasitic drug , which blocks endothelial cell proliferation and increases
tyrosine phosphorylation of many signalling proteins; associated with urticaria, paresthesias,
vomitino and neurologic toxicity; is used also to treat trypanosomiasis and onchocerciasis; to
functions as an heparanase inhibitor and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property ; also studied for the treatment of autism .
Suramin Sodium salt has been used :
- as a potent blocker of rat P2Y2 purinergic receptor ;
- to study it's effects on short circuit current (lsc) acress strial marginal cells ;
- to show it's effects on initial burst of glial activity ;
- to assess it's neuroprotective potential in rats ;
- as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine
- triphosphate (eATP) .
Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and
tumor cell metastasis; inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M
along with SIRT5 has also been observed; Suramin Sodium has been recorded to antagonize
EDG-3 (S1P3) selectively; Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4,
PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF ; it is used as a G
protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5; it also blocks calmodulin
binding to recognition sites and G protein coupling to G protein-coupled receptors; increases
open probability of ryanodine receptor (RyR) channels ; anticancer and antiviral agent
store in cool place ; keep container tightly closed in a dry and well-ventilated place *(1) ;
keep away from strong oxidizing agents *(1) ;
2 (two) years from production date (sealed package), * shipped in ambient (1) .
special for chemicals transport (according to IATA / ADR / ECHA-REACH rules / int.l laws).
C.O.A., MSDS, GMP, API, USP, EUP, ECHA-REACH, ORIGIN, etc...
(originals will be delivered with good , and copies after confirmed order )
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