technical file | : | C.O.A. |
product name synonyms product origin purity grade use product code C.A.S. number MDL EINECS molecular formula NACRES SMILES InChl InChl Key origin molecular weight melting point boiling point relative density storage temp. solubility assay (HPLC) appearance (color) form applications in vitro description note packaging/transport standardization | : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : | Picrocrocin , ACS - sterilized (R)-4-(β-D-Glucopyranosyloxy)-β-cyclocitral, Pikrocrocin, Saffron-bitter 100% made in European Union *(according to USP, EUP, Echa-Reach) >99.99% (raw matter, ultra-pure, selected) laboratory chemicals / tech. / pharmaceutical SA6529L 138-55-6 MFCD09752814 256-145-7 C16H26O7 NA.24 CC1=C(C(C[C@@H](C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)(C)C)C=O ; InChI=1S/C16H26O7/c1-8-4-9(5-16(2,3)10(8)6-17)22-15-14(21)13(20)12(19)11(7-18)23-15/h6,9,11-15,18-21H,4-5,7H2,1-3H3/t9-,11-,12-,13+,14-,15-/m1/s1 ; WMHJCSAICLADIN-WYWSWGBSSA-N ; plant / crocus sativus 330.37 196 °C 493.69 °C (predicted) ~1.3 g/cm3 (Predicted) 4 °C, protect from light (* in solvent : -80°C, 6 months; -20°C, 1 month (protect from light) soluble in water : 7707 mg/L. @25 °C (estimated) >99.99% <101.50% white to off-white powder Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells . Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells . Picrocrocin, derived from beta-cyclocitral, is a beta-D-glucoside that serves as a precursor to safranal. Within saffron, it plays a key role in imparting the distinct bitter taste. This compound is derived from beta-cyclocitral and acts as a monoterpene glycoside precursor to safranal. Saffron, obtained from the crocus flower, contains picrocrocin. In particular, picrocrocin is responsible for the pronounced bitter taste associated with saffron. During the drying process, picrocrocin undergoes the enzymatic action of glucosidase, liberating the aglycone (HTCC, C10H16O2). Subsequently, dehydration transforms the aglycone into safranal. It is worth mentioning that picrocrocin emerges as a degradation product of the carotenoid zeaxanthin. This product is for research use only, is not to be used for therapeutic; not intended for animal or human or diagnostic or therapeutic use , and cannot be sold to patients. Special for chemical transport (according to IATA / ADR / ECHA-REACH rules / int.l laws) . According to U.S. / E.U. Pharmacopoeia, Echa-Reach, UNI EN ISO 14001, G.M.P., M.S.D.S., etc... |
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