Price without discount€ 3470.00
*
possible additional
discount for large
quantity orders
technical file | : | C.O.A. |
product name synonyms product origin use product code c.a.s. number EINECS biological source recomninant techniques mammalian suitability assay (HPLC) form quantity storage features x x x x x x x x x x x x x x x x x x x x x x x x x x x x x note packaging/transport standardization | : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : | Follistatin human (HPLC) , sterilized FS, activins-binding protein 100% made in European Union *(according to USP, EUP, Echa-Reach) Tech. / Lab. / pharmaceutical / bio-research / cell culture ES5403A 7601-54-9 231-509-8 human expressed in E. coli cell culture suitable suitable for molecular biology >99.99% lyophilized (from 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5.) 20 μg (* micrograms) maintain refrigerated at 2-8°C for up to 6 months; for long term storage store at -20°C Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues; the gene is mapped to human chromosome 5q11.2. Recombinant human Follistatin is a 31.5kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain. Application: Follistatin human has been used to suppress myostatin signaling; It has also been used as an inhibitor of activin A. Biochem/physiol Actions: Follistatin is a multifunctional secreted protein that binds to ligands of the TGF (transforming growth factor)-β family and regulates their activity by inhibiting their access to signaling receptors ; It was originally discovered as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle-stimulating hormone) ; In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF (transforming growth factor)-β ligands including BMP (bone morphogenetic protein)-2,-4,-6,-7, Myostatin, GDF-11 (growth differentiation factor 11), and TGF-b1; in gonads, it is responsible for oocyte competence and embryo development. In the pituitary gland, it causes cyclic changes in FSH production in the estrous cycle. Follistatin also participates in bone metabolism. It controls inflammation, fibrosis, and tissue repair ; levels of plasma follistatin increase in polycystic ovary syndrome and type 2 diabetes. Follistatin might also be involved in tumor progression, including apoptosis, angiogenesis and metastasis Preparation: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN for research use only ; not for use in diagnostic procedures Special for chemical transport (according to IATA / ADR / ECHA-REACH rules / int.l laws) . According to U.S./E.U. Pharmacopoeia, Echa-Reach, UNI EN ISO 14001, G.M.P., MSDS, etc... |