Difloxacin Hydrochloride, API - eurchem.net2

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Difloxacin Hydrochloride , API
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid hdl.
API  ( veteritary medicine , Lab. / phama )
100% made in European Union  *(according to USP, EUP, ECHA-REACH)  
>99.99+% min.  (1st. matter , extra pure , selected)
EA63754
91296-86-5
MFCD03840489
C21H19F2N3O3•HCl
C21H20C1F2N3O3
435.85
fluoride : ≥7.8%
3.0 - 5.0
ambient temperature ( <30 °C )
soluble in aqueous buffer
≥ 99.99+% min.
≥ 7.8% (water content)
≤ 3.0 %
≤ 0.1 %
≤ 20ppm  
JFMGBGLSDVIOHL-NIIDSAIPSA-N
almost white to light yellow
cristalline free flowing powder
5 years
Difloxacin HCl is a fluoroquinolone antibiotic commonly used in veterinary medicine.
Difloxacin HCl is freely soluble in aqueous solution (5 mg/mL) .
Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA
strain  during  replication ; because  DNA  gyrase is required during  DNA  replication ,
subsequent DNA synthesis and ultimately cell division is inhibited .
Difloxacin is a broad spectrum antibiotic targeting a wide variety of Gram negative and
gram positive bacteria; in addition, Difloxacin is also effective against a few Mycoplasma
species including Mycobacterium tuberculosis
Difloxacin HCl is commonly used in clinical vitro microbiological antimicrobial susceptibility
tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial
isolates ; medical  microbiologists use  AST  results to recommend  antibiotic treatment
options for infected patients.Representative MIC values include:
Mycobacterium tuberculosis 0.5 µg/mL – 8 µg/mL
Escherichia coli 0.1875 µg/mL
complete list of difloxacin MIC values :  MIC50 (μg/ml)    MIC90 (μg/ml)    Range (μg/ml)
Escherichia coli (ATCC 8739)                  -                       0.1875               ? - ?
Escherichia coli (chicken isolate)             >16                   >16                  ? - ?
Escherichia coli (swine isolate)                >16                   >16                   ? - ?
Mycobacterium tuberculosis                       4                       4                   0.5 - 8
Staphylococcus aureus (ATCC 6538)        -                       0.125                 ? - ?
Wolfson J. S., David C. Hooper "The fluoroquinolones: structures, action mechanisms and
resistance, spectra of activity in vitro" American Society for microbiology 09/28/85: 581-86
according to E.U., ECHA-REACH, ADR , rules
MSDS, GMP, COA, API, and/or any other documents and certification, will be shipped in
originals with delivery of product, no copies will be sent without confirmation of order ;
the price of the product is NO NEGOTIBLE , already around 25% lower than the official
price of the International Chemical Stock Exchange / ICIS